Biljana  Musicki, Ph.D.
Biljana Musicki, Ph.D.

Assistant Professor, Urology
Johns Hopkins Medical Institutions
Marburg 420
600 North Wolfe Street
Baltimore, MD 21287

Office: (410) 955-0352


Fax: (410) 614-3695


Free Access to abstracts at PubMed


  1. Milenkovic L, Bogic L, Musicki B, Martinovic JV. Effects of aging on prolactin release after stress in female and male rats. Acta Endocrinol. (Copenh). 1984;107(3):337-339.

  2. Cross JC, Soodak LK, Musicki B, Behrman HR. Absence of phosphocreatine in rat luteal cells. Am. J. Physiol. 1987; 253(4 Pt1): E391-E394.

  3. Soodak LK, Musicki B, Behrman HR. Selective amplification of luteinizing hormone by adenosine in rat luteal cells. Endocrinology1988;122(3): 847-854.

  4. Musicki B, Aten RF, Behrman HR. The antigonadotropic actions of prostaglandin F2a and phorbol ester are mediated by separate processes in rat luteal cells. Endocrinology 1990; 126(3):1388-1395.

  5. Ivanisevic-Milovanovic O, Musicki B. Luteinization of ovaries and gonadotrophin and prolactin secretion in rats with posterior hypothalamic lesions. Endocr. Regulations 1992; 26(2):89-93.

  6. Musicki B, Behrman HR. Metal chelators reverse the action of hydrogen peroxide in rat luteal cells.  Mol. Cell. Endocrinol.1993;92(2):215-220.

  7. Musicki B, Aten RF, Behrman HR. Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells. Endocrinology 1994; 134(2):588-595.

  8. Musicki B, Kodaman PH, Aten RF, Behrman HR. Endocrine regulation of ascorbic acid transport and secretion in luteal cells. Biol. Reprod. 1996;54(2):399-406. 

  9. Musicki B, Pepe GJ, Albrecht ED. Functional differentiation of placental syncytiotrophoblasts during baboon pregnancy: developmental expression of chorionic somatomammotropin messenger ribonucleic acid and protein levels. J. Clin. Endocrinol. Metab. 1997;82(12):4105-4110.

  10. Hurt KJ, Musicki B, Palese MA. Crone JC, Becker RE, Moriaruty Jl, Snyder SH, Burnett AL (K.J.H and B.M. contributed equally to this work). Akt-dependent phosphorylation of endothelial nitric oxide synthase mediated penile erection. Proc. Natl. Acad. Sci. USA 2002; 99(6):4061-4066.

  11. Musicki B, Pepe GJ, Albrecht ED. Functional differentiation of the placental syncytiotrophoblast: Effect of estrogen on chorionic somatomammotropin expression during early primate pregnancy. J. Clin. Endocrinol. Metab. 2003;88(9):4316-4323.

  12. Desaulniers D, Leingartner K, Musicki B, Yagminas A, Xiao GH, Cole J, Marro L, Charbonneau  M, Tsang BK. Effects of postnatal exposure to mixtures of non-ortho-PCBs, PCDDs, and PCDFs  in prepubertal female rats. Toxicol. Sci. 2003;75(2):468-480.

  13. Musicki B, Palese MA, Crone JK, Burnett AL. Phosphorylated endothelial nitric oxide synthase mediates vascular endothelial growth factor-induced penile erection. Biol. Reprod. 2004;70(2):282-289.

  14. Desaulniers D, Leingartner K, Musicki B, Cole J, Li M, Charbonneau M, Tsang BK. Lack of effects of postnatal exposure to a mixture of aryl hydrocarbon-receptor agonists on the development of methylnitrosourea-induced mammary tumors in sprague-dawley rats. J. Toxicol. Environ. Health A. 2004;67(18):1457-1475.

  15. Desaulniers D, Xiao GH, Leingartner K, Chu I, Musicki B, Tsang B. Comparisons of brain, uterus and liver mRNA expression for cytochrome P450s, DNA methyltransferase-1, and catechol-o-methyltransferase in prepubertal female Sprague Dawley rats exposed to a mixture of aryl hydrocarbon receptor agonists. Toxicol. Sci. 2005;86(1):175-184. 

  16. Musicki B, Kramer MF, Becker RE, Burnett AL. Age-related changes in phosphorylation of endothelial nitric oxide synthase in the rat penis. J. Sex. Med. 2005;2(3):347-357. 

  17. Musicki B, Champion HC, Becker RE, Liu T, Kramer MF, Burnett AL. Erection capability is potentiated by  chronic sildenafil treatment: role of blood flow-induced endothelial nitric oxide synthase phosphorylation. Mol. Pharmacol. 2005;68(1):226-232.

  18. Musicki B, Kramer MF, Becker RE, Burnett AL. Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction. Proc. Natl. Acad. Sci. USA 2005;102(33):11870-11875.

  19. Musicki B, Champion HC, Becker RE, Kramer MF, Liu T, Sezen SF, Burnett AL. In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: no tachyphylaxis effect. J. Urol. 2005;174(4 Pt1):1493-1496. 

  20. Bivalacqua TJMusicki B,Usta MF, Champion HC, Kadowitz PJ, Burnett AL, Hellstrom WJG. Endothelial nitric oxide synthase gene therapy for erectile dysfunction. Curr. Pharm. Des. 2005;11(31):4059-4067.

  21. Burnett AL, Musicki B. The nitric oxide signaling pathway in the penis. Curr. Pharm. Des. 2005;11(31):3987-3994.

  22. Musicki B, Burnett AL. eNOS function and dysfunction in the penis. Exp. Biol. Med. 2006; 231(2):154-165.

  23. Hurt KJSezen SFChampion HCCrone JKPalese MAHuang PLSawa ALuo XMusicki BSnyder SHBurnett AL. Alternatively spliced neuronal nitric oxide synthase mediates penile erection. Proc. Natl. Acad. Sci. USA  2006;103(9):3440-3443.

  24. Burnett AL, Bivalacqua TJ, Champion HC, Musicki B. Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism. Urology 2006;67(5):1043-1048.

  25. Burnett AL, Musicki B, Jin L, Bivalacqua TJ. Nitric oxide/redox-based signalling as a therapeutic target for penile disorders. Expert Opin. Ther. Targets 2006;10(3):445-457. 

  26. Burnett ALBivalacqua TJChampion HCMusicki B. Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. J. Sex. Med. 2006;3(6):1077-1084. 

  27. Musicki B, Burnett AL. Endothelial dysfunction in diabetic erectile dysfunction. Int. J. Impot. Res. 2007;19(2);129-138.

  28. Bivalacqua TJLiu TMusicki BChampion HCBurnett AL. Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis. Eur. Urol. 2007;51(6):1732-1740

  29. Burnett AL, Bivalacqua TJ, Musicki B. Molecular science of priapism. Current Sexual Health Reports 2007;4;9-14.

  30. Musicki B, Liu T, Strong T, Jin L, Laughlin MH, Turk JR, Burnett AL. Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysis J. Sex. Med. 2008;5(3);552-561.  

  31. Burnett AL, Musicki B, Jin L, Bivalacqia TJ. Nitric oxide/redox-based signalling as a therapeutic target for penile disorders. Expert Opin. Ther. Targets 2008;10(3):445-457.

  32. Burnett AL, Strong T, Trock BJ, Jin L, Bivalacqua TJ, Musicki B. Serum biomarker measurements of endothelial function and oxidative stress after daily dosing of sildenafil in type 2 diabetic men with erectile dysfunction. J. Urol. 2009;18(1):245-251.  

  33. Musicki B, Liu T, Lagoda GA, Bivalacqua TJ, Strong TD, Burnett AL. Endothelial nitric oxide synthase regulation in female genital tract structures. J. Sex. Med. 2009; Suppl 3:247-253.  

  34. Musicki B, Ross AE, Champion HC, Burnett AL, Bivalacqua TJ. Post-translational modification of constitutive nitric oxide synthase in the penis. J. Androl. 2009;30(4):352-362.  

  35. Bivalacqua TJ, Musicki B, Hsu LL, Gladwin MT, Burnett AL, Champion HC. Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism. J. Sex. Med. 2009;6(9):2494-2504.  

  36. Musicki B. Molecular mechanisms of penile erection and erectile dysfunction.  Med Data Rev. 2009;2:25-30. 

  37. Musicki B, Burnett AL. Endothelial nitric oxide (eNOS) regulation. Med Data Rev. 2010;2:29-34. 

  38. Musicki B, Liu T, Strong TD, Lagoda GA, Bivalacqua TJ, Burnett AL. Posttranslational regulation of endothelial nitric oxide synthase (eNOS) by estrogens in the rat vagina. Sex Med. 2010;7(5):1768-1777.

  39. Bivalacqua TJ, Ross AE, Strong TD, Gebska MA, Musicki B, Champion HC, Burnett AL. Attenuated RhoA/Rho-kinase Signaling in the Penis of Transgenic Sickle Cell Mice. Urology 2010;76(2):510.e7-12. (1 + 1 citat)

  40. Musicki B, Liu T, Lagoda GA, Strong TD, Sezen SF, Johnson JM, Burnett AL. Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase. J Sex Med. 2010;7(9):3023-3032.

  41. Musicki B, Champion HC, Hsu LL, Bivalacqua TJ, Burnett AL. Post-translational inactivation of endothelial nitric oxide synthase in the transgenic sickle cell mouse penis. J Sex Med. 2011;8(2):419-426. 

  42. Johnson JM, Bivalacqua TJ, Lagoda GA, Burnett AL, Musicki B. eNOS-uncoupling in age-related erectile dysfunction. Int J Impot Res. 2011;23(2):43-48.

  43. Lagoda G, Xie Y, Sezen SF, Hurt KJ, Liu L, Musicki B, Burnett AL. FK506 neuroprotection after cavernous nerve injury is mediated by thioredoxin and glutathione redox systems. J Sex Med. 2011;8(12):3325-3334. 

  44. Bivalacqua TJ, Musicki B, Kutlu O, Burnett AL. New Insights into the Pathophysiology of Sickle Cell Disease-Associated Priapism. J Sex Med 2012;9(1):79-87.

  45. Musicki B, Liu T, Sezen SF, Burnett AL. Targeting NADPH Oxidase Decreases Oxidative Stress in the Transgenic Sickle Cell Mouse Penis. J Sex Med. 2012;9(8):1980-1987.

  46. Lagoda G, Sezen SF, Cabrini MR, Musicki B, Burnett AL. Molecular Analysis of Erection Regulatory Factors in Sickle Cell Disease Associated Priapism in the Human Penis. J Urol. 2013;189(2):762-768.

  47. Hurt KJ, Sezen SF, Lagoda GF, Musicki B, Rameau GA, Snyder SH, Burnett AL. Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16624-9.

  48. Bivalacqua TJ, Musicki B, Hsu LL, Berkowitz DE, Champion HC, Burnett AL. Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress. PLoS One 2013;8(7):e68028.

  49. Musicki B, Bivalacqua TJ, Champion HC, Burnett AL. Sildenafil Promotes eNOS Activation and Inhibits NADPH Oxidase in the Transgenic Sickle Cell Mouse Penis. J Sex Med 2014;11:424-430.

  50. Sezen SF, Lagoda G, Musicki B, Burnett AL. Hydroxyl fasudil, an inhibitor of Rho signaling, improves erectile function in diabetic rats: a role for neuronal ROCK. J Sex Med 2014;11:2164-2171.

  51. Burnett AL, Sezen SF, Hoke A, Caggiano AO, Iaci J, Lagoda G, Musicki B, Bella AJ. GGF2 Is Neuroprotective in a Rat Model of Cavernous Nerve Injury-Induced Erectile Dysfunction. J Sex Med 2015;12:897-905.

  52. Musicki B, Zhang Y, Chen H, Brown TR, Zirkin BR, Burnett AL. Mechanism of testosterone deficiency in the transgenic sickle cell mouse. PLoS One 2015;10(5):e0128694.

  53. Sopko NA, Matsui H, Hannan JL, Berkowitz D, Champion HC, Hsu LL, Musicki B, Burnett AL, Bivalacqua TJ. Subacute hemolysis in sickle cell mice causes priapism secondary to NO imbalance and PDE5 dysregulation. J Sex Med 2015;12(9):1878-1885.

  54. Musicki B, Bella AJ, Bivalacqua TJ, Davies KP, DiSanto ME, Gonzalez-Cadavid NF, Hannan JL, Kim NN, Podlasek CA, Wingard CJ, Burnett AL. Basic Science Evidence for the Link Between Erectile Dysfunction and Cardiometabolic Dysfunction. J Sex Med 2015, December, DOI: 10.1111/jsm.13069

Book Chapters:

  1. Behrman HR, Aten RF, Ireland JJ, Soodak LK, Pepperell JR, Musicki B. 1987: Luteolysis   and mechanisms of luteolysis. In: The Primate Ovary. Stouffer RL (Ed), Plenum Publishing, New York, pp. 175-190.

  2. Behrman HR, Preston SL, Aten RF, Pepperell JR, Musicki B, Margolin Y. 1989: Phorbol ester inhibits cyclic AMP accumulation and induces oocyte maturation in oocyte-cumulus complexes. Further evidence that oocyte maturation may be regulated by control of FSH action. In:  Follicular Development and the Ovulatory Response. N. Dekel and A. Tsafriri (Eds), Raven Press, pp. 97-106.

  3. Behrman HR, Aten RF, Pepperell JR, Riley JCM, Wang F, Endo T, Musicki B. 1992: Activation of hydrogen peroxide production in the ovary: a process that mediates corpus luteum regression. In: Local Regulation of Ovarian Function, N.O. Sjoberg, L. Hamberger, P.O. Janson, Ch. Owman and H.J.T. Coelingh Bennick (Eds), Parthenon Publishing Co., Carnforth, U.K., pp. 297-306.

  4. Behrman HR, Aten RF, Endo T, Lee G, Musicki B, Penzias AS, Riley JCM, Wang F. 1993: Luteal arrest and ovarian reactive oxygen. In: Local Systems in Reproduction, Ares-Serono Symposia, R.R. Magness and F. Naftolin (Eds), Raven Press, New York, 96: pp. 99-109.

  5. Behrman HR, Endo T, Aten RF, Musicki B. 1993: Corpus luteum function and regression. In: Reproductive Medicine Review, S.K.Smith (ed), Edward Arnold Publishing, Kent, U.K., 2: pp. 153-180.

  6. Musicki B, Burnett AL. 2009: Pathophysiology of Erectile Dysfunction: Molecular Basis. In: Textbook of Erectile Dysfunction [2nd Edition], C. Carson, R. Kirby, I. Goldstein (eds). Informa Healthcare USA; pp. 72-82.

  7. Bivalacqua TJ, Musicki B, Champion HC, Burnett AL. 2009: Phosphodiesterase Type 5 Inhibitor Therapy for Priapism. In: Textbook of Erectile Dysfunction [2nd Edition], C. Carson, R. Kirby, I. Goldstein (eds). Informa Healthcare USA; pp. 428-433.

  8. Musicki B, Burnett AL. 2012: Role of oxidative stress in ED: unraveling the molecular mechanism. In: Studies on Men’s Health and Fertility. Ashok Agarwal A, Aitken J, Alvarez J (eds). Humana Press; pp. 617-643.

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