,
Phuoc T. Tran, MD PhD

Clinical Director of Radiation Oncology and Molecular Radiation Sciences
Associate Professor of Radiation Oncology and Molecular Radiation Sciences
Johns Hopkins Medicine
Appointments: 410-502-8000

Email: tranp@jhmi.edu

Expertise

Adrenal Cancer, Bladder Cancer, Image-Guided Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Metastatic Bone Disease, Metastatic Disease, Oligometastatic Disease, Penile Cancer, Prostate Cancer, Radiation Oncology, Stereotactic Body Radiation Therapy, Testicular Cancer, Urethral Cancer

Research Interests

Radiosensitizers; Genetically engineered mouse models of disease; Epithelial Plasticity (Epithelial-Mesenchymal Transition and Mesenchymal-Epithelial Transition)
Dr. Tran's research focuses on the improvement of clinical radiotherapy for the treatment of adrenal, bladder, penile, prostate, testicular and urethral cancer. To learn how tumors grow and why some cancers are resistant to treatment, he studies the transitions of epithelial and mesenchymal cellular states in transgenic mouse models.

Additionally, Dr. Tran is working with colleagues from top-ranked institutions nationwide to establish a National Radiation Oncology Registry. The purpose of the registry is to improve the care of cancer patients by capturing and studying information about cancer treatments and outcomes.

Biography

Dr. Phuoc T. Tran is an associate professor of radiation oncology and molecular radiation sciences, oncology and urology at the Johns Hopkins School of Medicine.

Dr. Tran is the Clinical Director of Radiation Oncology at the Sidney Kimmel Comprehensive Cancer Center and treats patients with cancers of the genitourinary system and uses stereotactic radiation techniques (such as SRS and SBRT/SABR) for the treatment of patients with oligometastatic disease. His research focuses on the improvement of clinical radiotherapy for the treatment of adrenal, bladder, penile, prostate, testicular and urethral cancer as well as patients with oligometastatic disease.

 



Education

Training

  • Oregon Health & Sciences University (Portland OR ) (2003)

Residencies

  • Stanford University School of Medicine / Radiation Oncology (Stanford CA ) (2008)

Certifications

  • Radiation Oncology, American Board of Radiology (2009)

 



Licensure & Certifications

  • Under Construction


Publications

Selected Publications


View all on PubMed
  1. Tran PT*,+, Shroff EH*, Burns TF*, Thiyagarajan S, Das ST, Zabuawala T, Chen J, Cho YJ, Luong R, Tamayo P, Salih T, Aziz K, Adam SJ, Vicent S, Nielsen CH, Withofs N, Sweet-Cordero A, Gambhir SS, Rudin CM, Felsher DW+. "Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis." PLoS Genet. 2012;8(5):e1002650. doi: 10.1371/journal.pgen.1002650. Epub 2012 May 24. * - these authors contributed equally; and + - corresponding authors.
  2. Timothy F. Burns, Irina Dobromilskaya, Sara C. Murphy, Rajendra P. Gajula, Saravanan Thiyagarajan, Sarah S. Chatley, Khaled Aziz, Yoon-Jae Cho, Phuoc T. Tran, and Charles M. Rudin. Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene Driven Non-Small Cell Lung Cancer. Mol Cancer Res 11 (2013) 329-338.
  3. Tran PT, Bendapudi PK, Lin HJ, Choi P, Koh S, Chen J, Horng G, Hughes NP, Schwartz LH, Miller VA, Kawashima T, Kitamura T, Paik D, Felsher DW. "Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation." Sci Transl Med. 2011 Oct 5;3(103):103ra99. doi: 10.1126/scitranslmed.3002018.
  4. Jason A. Efstathiou, Deborah S. Nassif, Todd R. McNutt, C. Bob Bogardus, Walter Bosch, Jeff Carlin, Ron C. Chen,  Henry Chou, Dave Eggert, Benedick  Fraass, Joel Goldwein, Karen E. Hoffman, Ken Hotz, Margie Hunt, Marc Kessler, Colleen A. F. Lawton, Chuck Mayo, Jeff M. Michalski, Sasa Mutic, Louis Potters, Chris M. Rose, Howard M. Sandler, Greg Sharp, Wolfgang Tomé, Phuoc T. Tran, Terry Wall, Anthony L. Zietman, Peter E. Gabriel, Justin E. Bekelman.  Practice-Based Evidence to Evidence-Based Practice: Building the National Radiation Oncology Registry.  J Oncol Pract 9 (2013) e90-95.
  5. Aaron T. Wild*, Nishant Gandhi*,Sivarajan T. Chettiar, Khaled Aziz, Rajendra P. Gajula, Russell D. Williams, Rachit Kumar, Kekoa Taparra, Jing Zeng,  Jessica A, Cades, Esteban Velarde, Siddharth Menon, Jean-Francois Geschwind, David Cosgrove, Timothy M. Pawlik, Anirban Maitra, John Wong, Russell K. Hales, Michael Torbenson,  Joseph M. Herman+, Phuoc T. Tran+.  Concurrent versus sequential sorafenib therapy in combination with radiation for hepatocellular carcinoma.  PLoS ONE 8 (2013) e65726.
  6. Rajendra P. Gajula*, Sivarajan T. Chettiar*, Russell D. Williams, Saravanan Thiyagarajan, Yoshinori Kato, Khaled Aziz, Ruoqi Wang, Nishant Gandhi, Aaron T. Wild, Farhad Vesuna, Jinfang Ma, Tarek Salih, Jessica Cades, Elana Fertig, Shyam Biswal, Timothy F. Burns, Christine Chung, Charles M. Rudin, Joseph M. Herman, Russell K. Hales, Venu Raman, Steven An, Phuoc T. Tran.  The twist box domain is required for Twist1-induced prostate cancer metastasis. Mol Cancer Res 11 (2013) 1387-1400**. PMID: 23982216. PMCID: PMC3833995. * - these authors contributed equally. ** - Cover illustration and Highlighted in Mol Cancer Res.
  7. Zhou H, Rodriguez M, van den Haak F, Nelson G, Jogani R, Xu J, Zhu X, Xian Y, Tran PT, Felsher DW, Keall PJ, Graves EE. "Development of a MicroCT-Based Image-Guided Conformal Radiotherapy System for Small Animals." Int J Radiat Oncol Biol Phys. 2010 Sep 1;78(1):297-305. doi: 10.1016/j.ijrobp.2009.11.008. Epub 2010 Apr 13.
  8. Nielsen CH, Kimura RH, Withofs N, Tran PT, Miao Z, Cochran JR, Cheng Z, Felsher D, Kjær A, Willmann JK, Gambhir SS. "PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model with a Novel 64Cu-DOTA-Knottin Peptide." Cancer Res. 2010 Nov 15;70(22):9022-30. doi: 10.1158/0008-5472.CAN-10-1338. Epub 2010 Nov 9.

Lab

Dr. Tran and his laboratory focus their studies on the transitions between epithelial and mesenchymal cellular states and the implications of these transitions for tumorigenesis, cancer treatment resistance and radiation-induced fibrosis. Their research utilizes a variety of inducible transgenic mouse models and non-invasive rodent imaging.

One of these transitions, known as epithelial-mesenchymal transition (EMT), is a conserved developmental program that when inappropriately activated in post-natal life has been associated with organ fibrosis, tumorigenesis and metastasis. A major focus of the laboratory is the use of inducible mouse models to simulate molecularly targeted therapies for malignancies and radiation induced late effects. Another focus of the laboratory is the study of novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy.

The Tran lab is committed to translating discoveries from the laboratory bench into novel cancer prevention, diagnostic and treatment approaches that can be tested in the clinic.

Clinical Trials

Radiation and Androgen Ablation for Prostate Cancer

MRI for Assessing Prostate Cancer Response

Stereotactic Body Radiation with Nelfinavir for Oligometastases

 



Memberships

  • Under Construction


Awards & Honors

National Cancer Institute 1R01CA166348-01A1, 2013-2018

Sidney Kimmel Translational Scholar Award. 2013-2015

Patrick C. Walsh Prostate Cancer Research Fund Award, 2013-2014

Alpha Omega Alpha Honor Medical Society Alumni Award, Oregon Health & Sciences University Chapter, 2013

Oregon Health & Sciences University School of Medicine Alumni Association Early Career Achievement Award, 2013

American Cancer Society Research Scholar, 2012-2016

Uniting Against Lung Cancer Award, 2012-2014

Included among Top Doctors by Baltimore Magazine, 2012

Association of Residents in Radiation Oncology (ARRO) Educator of The Year, 2012

DoD Prostate Cancer Physician Research Training Award, 2011-2016

The Phyllis and Brian L. Harvey Scholar - Patrick C. Walsh Prostate Cancer Research Fund Award, 2011-2013

ASTRO Junior Faculty Career Research Training Award, 2009-2011

Parker B. Francis Fellow, 2008-2011

Radiological Society of North America Research Fellow, 2008

Henry S. Kaplan Research Fellow, 2007

Malcolm A. Bagshaw Award, 2007

ASCO/AACR Methods in Clinical Cancer Research Workshop Scholarship, 2007

Radiological Society of North America Research Resident, 2006

Radiological Society of North America Roentgen Resident Research Award, 2006

OHSU Deans Medical Student Research Award, 2003

OHSU Molecular Hematology Research Training Fellow, 1998-2001

OHSU Laurel Merit MD/PhD Scholar, 1996-2003

Graduated magna cum laude from University of California, San Diego, 1996

University of California Regents Scholar, 1995-1996

John Muir College Caledonian Honor Society, University of California, San Diego, 1995